Article

Changes in the mutational dynamics of the SARS-CoV-2 main-protease substantiate the danger of emerging resistance to antiviral drugs.

2022-09-22

Abstract excerpt

<title>Abstract</title>The current coronavirus pandemic is being combated worldwide by nontherapeutic measures and massive vaccination programs. Nevertheless, therapeutic options such as SARS-CoV-2 main-protease (Mpro) inhibitors are essential due to the ongoing evolution toward escape from natural or induced immunity. While antiviral strategies are vulnerable to the effects of viral mutation, the re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bdd8e3f9-14f6-59cd-9e1f-75949553bf0d
DOI: 10.21203/rs.3.rs-1858067/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Changes in the mutational dynamics of the SARS-CoV-2 main-protease substantiate the danger of emerging resistance to antiviral drugs.DOI 10.21203/rs.3.rs-1858067/v2Read

Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitorsSemantic proximity Read

Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvirSemantic proximity Read

Genetic surveillance of SARS-CoV-2 M pro reveals high sequence and structural conservation prior to the introduction of protease inhibitor PaxlovidSemantic proximity Read

A comprehensive study of SARS-CoV-2 main protease (M pro ) inhibitor-resistant mutants selected in a VSV-based systemSemantic proximity Read

Monitoring for SARS-CoV-2 drug resistance mutations in broad viral populationsSemantic proximity Read

Hotspot residues and resistance mutations in the nirmatrelvir-binding site of SARS-CoV-2 main protease: Design, identification, and correlation with globally circulating viral genomes.Semantic proximity Read

Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain ResistanceSemantic proximity Read

Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitorsSemantic proximity Read

Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to NirmatrelvirSemantic proximity Read

Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir (PF-07321332)Semantic proximity Read

Predicting Antiviral Resistance Mutations in SARS-CoV-2 Main Protease with Computational and Experimental Screening.Semantic proximity Read

Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of NirmatrelvirSemantic proximity Read