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Article

SARS-CoV-2 main protease mutation analysis via a kinematic method.

Proteins - 1 Nov 2023

Chen Xiyu, Leyendecker Sigrid, van den Bedem Henry

Abstract excerpt

The Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) is the virus responsible for the COVID-19 pandemic. COVID-19 continues to cause millions of deaths globally in part due to immune-evading mutations. SARS-CoV-2 main protease (Mpro) is an important enzyme for viral replication and potentially an effective drug target. Mutations affect the dynamics of enzymes and thereby their activity and ability to...

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PMID: 37408369
DOI: 10.1002/prot.26543

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