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Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma

2023-09-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cell free DNA (cfDNA) profiles of 5-hydroxymethylcytosine (5-hmC), an epigenetic marker of open chromatin and active gene expression, are correlated with metastatic disease burden in patients with neuroblastoma. Neuroblastoma tumors are comprised of adrenergic (ADRN) and mesenchymal (MES) cells, and the relative abundance of each in tumor biopsies has prognostic implications...

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Literature Corpus work
430cec72-049b-574c-9c19-19cc804b747e
DOI
10.1101/2023.08.30.554943
Open publication

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Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastomaDOI 10.1101/2023.08.30.554943
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