Epigenetic Liquid Biopsy Enables Universal Mutation-Agnostic Molecular Surveillance for High-Risk Neuroblastoma.

doi:10.1158/1078-0432.CCR-26-0457

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Article

Epigenetic Liquid Biopsy Enables Universal Mutation-Agnostic Molecular Surveillance for High-Risk Neuroblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2026

Gal-Mark Nurit, Grunwald Assaf, Gahramanov Valid, Hameiri-Grossman Michal, Shinderman-Maman Elena, Gaas Dafna, Shichrur Keren, Mordoukh Jacques, Oniashvili Nino, Chausky Barzakh Eva, Sever Aviv, Amar Shirah, Ash Shifra, Birger Yehudit, Izraeli Shai, Ebenstein Yuval, Berko Esther R

Abstract excerpt

PURPOSE: Liquid biopsy monitoring in pediatric solid tumors is limited by low mutational burden and lack of trackable genomic drivers. We sought to develop a mutation-agnostic, methylation-based liquid biopsy framework enabling universal molecular surveillance of high-risk neuroblastoma. EXPERIMENTAL DESIGN: Using whole-genome Oxford Nanopore Technologies sequencing of high-risk neuroblastoma tumors, we compared...

Read the complete abstract on PubMed

Topics

Humans
Neuroblastoma
Liquid Biopsy
DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Biomarkers, Tumor

Male

Epigenesis, Genetic

Female

Child

Infant

Child, Preschool

Cell-Free Nucleic Acids

Circulating Tumor DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 42384765
DOI: 10.1158/1078-0432.CCR-26-0457
PMCID: PMC13575560

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