Article

<i>TP53</i> -mutant AML with ribosomal gene loss exhibits impaired protein translation and sensitivity to HSP90 inhibition

2025-10-02

Abstract excerpt

TP53 -mutated acute myeloid leukemia (AML) represents a particularly aggressive and therapeutically refractory subtype of the disease. While recurrent chromosomal abnormalities such as -5/del(5q), -7/del(7q), and del(17p) are well studied in this context, additional co-occurring events remain less well defined. Using the multi-dimensional Leucegene dataset (∼700 primary AML specimens), we identified and comprehens...

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Literature Corpus work: 42d4543b-e2d6-580c-b06d-4de6ba66239e
DOI: 10.1101/2025.10.01.679539

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