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Article

TP53-mutant AML with ribosomal gene loss exhibits impaired protein translation and sensitivity to HSP90 inhibition.

Science advances - 15 May 2026

Spinella Jean-François, Chagraoui Jalila, Moison Céline, Boivin Isabel, Carpentier Guillaume Richard, Mayotte Nadine, Béliveau François, Lavallée Vincent P, Hébert Josée, Sauvageau Guy

Abstract excerpt

TP53-mutated acute myeloid leukemia (AML) represents a particularly aggressive and therapeutically refractory subtype of the disease. While recurrent chromosomal abnormalities such as -5/del(5q), -7/del(7q), and del(17p) are well studied in this context, additional co-occurring events remain less well defined. Using the multidimensional Leucegene dataset (~700 primary AML specimens), we identified and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 42139355
DOI: 10.1126/sciadv.aed7122
PMCID: PMC13178563

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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