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Epigenetic therapy combinations in acute myeloid leukemia: what are the options?

1 Jan 2019

Abstract excerpt

Epigenetics refers to the regulation of gene expression mainly by changes in DNA methylation and modifications of histone proteins without altering the actual DNA sequence. While epigenetic modifications are essential for normal cell differentiation, several driver mutations in leukemic pathogenesis have been identified in genes that affect epigenetic processes, such as DNA methylation and histone acetylation....

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PMID: 30719265
DOI: 10.1177/2040620718816698

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