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Human chondrogenic paraxial mesoderm, directed specification and prospective isolation from pluripotent stem cells

13 Jun 2012

Abstract excerpt

Directed specification and prospective isolation of chondrogenic paraxial mesoderm progeny from human pluripotent stem (PS) cells have not yet been achieved. Here we report the successful generation of KDR(-)PDGFRα(+) progeny expressing paraxial mesoderm genes and the mesendoderm reporter MIXL1-GFP in a chemically defined medium containing the canonical WNT signaling activator, BMP-inhibitor, and the...

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PMID: 22701159
DOI: 10.1038/srep00455

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