Article
Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy.
Scientific reports - 1 Jan 2012
Patel Shyam A, Ramkissoon Shakti H, Bryan Margarette, Pliner Lillian F, Dontu Gabriela, Patel Prem S, Amiri Sohrab, Pine Sharon R, Rameshwar Pranela
Abstract excerpt
The bone marrow (BM) is a major organ of breast cancer (BC) dormancy and a common source of BC resurgence. Gap junctional intercellular communication (GJIC) between BC cells (BCCs) and BM stroma facilitates dormancy. This study reports on a hierarchy of BCCs with the most immature subset (Oct4(hi)/CD44(hi/med)/CD24(-/+)) demonstrating chemoresistance, dormancy, and stem cell properties: self-renewal, serial...
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