Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

4′-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo

3 May 2024

Abstract excerpt

ABSTRACT Chikungunya virus (CHIKV) is an enveloped, positive-sense RNA virus that has re-emerged to cause millions of human infections worldwide. In humans, acute CHIKV infection causes fever and severe muscle and joint pain. Chronic and debilitating arthritis and joint pain can persist for months to years. To date, there are no approved antivirals against CHIKV. Recently, the ribonucleoside analog...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Mosquito-borne diseases and control
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38700353
DOI: 10.1128/mbio.00420-24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

4′-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivoPMID 38700353Read ↗

Identification and Characterization of Novel Chikungunya Virus Polymerase InhibitorsSemantic proximity Read ↗

4’-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza virusesSemantic proximity Read ↗

Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read ↗

Emetine dihydrochloride inhibits Chikungunya virus nsP2 helicase and shows antiviral activity in the cell culture and mouse model of virus infectionSemantic proximity Read ↗

Characterization of β- d - N 4 -Hydroxycytidine as a Novel Inhibitor of Chikungunya VirusSemantic proximity Read ↗

Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses in vitro and in vivoSemantic proximity Read ↗

4’-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replicationSemantic proximity Read ↗

Oral 4’-fluorouridine completely suppresses epidemic Oropouche virus replication in mice and confers protection against virus-induced diseaseSemantic proximity Read ↗

Substrate and target selectivity of 4′-fluoroadenosine against viral and host polymerasesSemantic proximity Read ↗

6'-β-Fluoro-Homoaristeromycin and 6'-Fluoro-Homoneplanocin A Are Potent Inhibitors of Chikungunya Virus Replication through Their Direct Effect on Viral Nonstructural Protein 1.Semantic proximity Read ↗

Nifuroxazide Prevents Chikungunya Virus Infection Both In Vitro and In Vivo via Suppressing Viral ReplicationSemantic proximity Read ↗

Chikungunya virus drug discovery: still a long way to go?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.