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Article

Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMN

1 May 2019

Abstract excerpt

BACKGROUND: Exposure to anesthetics during early life may impair cognitive functions. However, the underlying mechanisms remain largely unknown. We set out to determine effects of sevoflurane anesthesia on folate metabolism and myelination in young non-human primates, mice and children. METHODS: Young rhesus macaque and mice received 2.5 to 3% sevoflurane daily for three days. DNA and RNA sequencing and...

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PMID: 31060905
DOI: 10.1016/j.ebiom.2019.04.048

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