Article

Hypoxia-conditioned HNSCC cell line secretomes drive phenotypic, functional, and transcriptional reprogramming of human neutrophils

2026-07-31

Abstract excerpt

Neutrophils display marked functional plasticity in cancer; however, it remains poorly understood how soluble factors derived from hypoxic and irradiated head and neck squamous cell carcinoma (HNSCC) cells reprogram neutrophil phenotype and function. Here, we employed a well characterized and controlled in vitro model to examine how tumor-conditioned media (TCM) from HNSCC cell lines cultured under ambient (21% O...

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Literature Corpus work: 41c3edde-e298-5b16-ace9-05af74cdb3b4
DOI: 10.64898/2026.07.31.741959

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