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Article

Gene Expression Changes of Sonic Hedgehog Signaling Cascade in a Mouse Embryonic Model of Fetal Alcohol Syndrome

1 Nov 2005

Abstract excerpt

Fetal alcohol syndrome (FAS) is a congenital anomaly attributable to prenatal maternal excessive intake of ethanol. The authors made a mammalian model of FAS by culturing mouse embryos with high ethanol for embryonic day 7.8 to 9.5 in the whole embryo culture system. The embryos exposed to high ethanol were smaller and less advanced in development than were the embryos in the control group and showed craniofacial...

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PMID: 16327553
DOI: 10.1097/01.scs.0000183470.31202.c9

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