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Crystal Structures of Cisplatin Bound to a Human Copper Chaperone

16 Sept 2009

Abstract excerpt

Copper trafficking proteins, including the chaperone Atox1 and the P(1B)-type ATPase ATP7B, have been implicated in cellular resistance to the anticancer drug cisplatin. We have determined two crystal structures of cisplatin-Atox1 adducts that reveal platinum coordination by the conserved CXXC copper-binding motif. Direct interaction of cisplatin with this functionally relevant site has significant implications...

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PMID: 19807176
DOI: 10.1021/ja906363t

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