Article

Integrative In Silico Analysis of Synonymous Variants in ABCG2 and PPARA: Implications for Valproate Resistance in Epilepsy

2026-08-14

Abstract excerpt

<title>Abstract</title> <p> Epilepsy affects millions worldwide, and approximately one-third of patients develop resistance to antiseizure medications such as valproic acid (VPA). The <italic>ABCG2</italic> transporter and its transcriptional regulator <italic>PPARA</italic> have been implicated in VPA response, yet the contribution of synonymous single nucleotide polymorphisms (sSNPs) in these genes to VPA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 418aee5b-ca40-5b30-b57d-aaaba9b66c85
DOI: 10.21203/rs.3.rs-10508284/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative In Silico Analysis of Synonymous Variants in ABCG2 and PPARA: Implications for Valproate Resistance in EpilepsyDOI 10.21203/rs.3.rs-10508284/v1Read

Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes.Semantic proximity Read

Potential dysfunctional effects of synonymous variants: Insights from an exhaustive in silico analysis of the ABCB4 gene.Semantic proximity Read

Functional non-synonymous polymorphisms prediction methods: current approaches and future developments.Semantic proximity Read

Genetic variation in G-protein-coupled receptors--consequences for G-protein-coupled receptors as drug targets.Semantic proximity Read

Pharmacogenomic Profiling of Selected Genes Influencing Anti-Diabetic Drug Response in the Pakistani Pashtun Population: Shifting from Trial-and-Error to Precision MedicineSemantic proximity Read

Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics.Semantic proximity Read

Understanding the contribution of synonymous mutations to human disease.Semantic proximity Read

Pathogenicity Prediction of GABA <sub>A</sub> Receptor Missense VariantsSemantic proximity Read

PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters.Semantic proximity Read

A comprehensive in silico analysis of the functional and structural consequences of the deleterious missense nonsynonymous SNPs in human GABRA6 geneSemantic proximity Read

G protein-coupled receptor (GPCR) pharmacogenomicsSemantic proximity Read

Exposing synonymous mutations.Semantic proximity Read