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Article

Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.

The Journal of biological chemistry - 1 Jan 2000

Ceraudo Emilie, Horioka Mizuho, Mattheisen Jordan M, Hitchman Tyler D, Moore Amanda R, Kazmi Manija A, Chi Ping, Chen Yu, Sakmar Thomas P, Huber Thomas

Abstract excerpt

Uveal melanoma is the most common eye cancer in adults and is clinically and genetically distinct from skin cutaneous melanoma. In a subset of cases, the oncogenic driver is an activating mutation in CYSLTR2, the gene encoding the G protein-coupled receptor cysteinyl-leukotriene receptor 2 (CysLTR2). The mutant CYSLTR2 encodes for the CysLTR2-L129Q receptor, with the substitution of Leu to Gln at position 129...

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Identifiers

PMID: 33288675
DOI: 10.1074/jbc.RA120.015352
PMCID: PMC7948404

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Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.PMID 33288675Read ↗

Uveal Melanoma Oncogene <i>CYSLTR2</i> Encodes a Constitutively Active GPCR Highly Biased Toward Gq SignalingSemantic proximity Read ↗

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Endothelin signaling promotes melanoma tumorigenesis driven by constitutively active GNAQ.Semantic proximity Read ↗

Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma.Semantic proximity Read ↗

Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma.Semantic proximity Read ↗

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