Article
Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.
BMC cancer - 15 Feb 2021
Nell Rogier J, Menger Nino V, Versluis Mieke, Luyten Gregorius P M, Verdijk Robert M, Madigan Michele C, Jager Martine J, van der Velden Pieter A
Abstract excerpt
BACKGROUND: Activating Gαq signalling mutations are considered an early event in the development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, CYSLTR2 (encoding G-protein coupled receptor CysLT2R) forms a rare alternative. The role of wild-type CysLT2R in uveal melanoma remains unknown. METHODS: We performed a digital PCR-based molecular analysis of benign choroidal nevi and primary...
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