Article
Primary and Secondary Cone Cell Death Mechanisms in Inherited Retinal Diseases and Potential Treatment Options.
International journal of molecular sciences - 10 Jan 2022
Brunet Alicia A, Harvey Alan R, Carvalho Livia S
Abstract excerpt
Inherited retinal diseases (IRDs) are a leading cause of blindness. To date, 260 disease-causing genes have been identified, but there is currently a lack of available and effective treatment options. Cone photoreceptors are responsible for daylight vision but are highly susceptible to disease progression, the loss of cone-mediated vision having the highest impact on the quality of life of IRD patients. Cone...
Topics
- Animals
- Apoptosis
- Autophagy
- Biomarkers
- Cell Death
- Endoplasmic Reticulum Stress
- Genetic Association Studies
- Genetic Diseases, Inborn
- Genetic Predisposition to Disease
- Humans
- Oxidative Stress