Article

Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across pediatric and AYA sarcomas

2023-07-21

Abstract excerpt

No targeted agents are approved for pediatric sarcomas. Tyrosine kinase (TK) inhibitors represent attractive therapeutic candidates, however, beyond rare TK-activating fusions or mutations, predictive biomarkers are lacking. RNA overexpression of TKs is more commonly observed in pediatric sarcomas, however, an unresolved question is when upregulated TK expression is associated with kinase activation and signaling...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 410ee207-8228-5556-b7a6-5b36d352cf7d
DOI: 10.1101/2023.07.19.548825

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across pediatric and AYA sarcomasDOI 10.1101/2023.07.19.548825Read

Multidimensional Characterization of Soft-Tissue Sarcomas with FUS-TFCP2 or EWSR1-TFCP2 FusionsSemantic proximity Read

Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusionsSemantic proximity Read

Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Pediatric PatientsSemantic proximity Read

Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra.Semantic proximity Read

Next-Generation Sequencing Identifies Potential Actionable Targets In Pediatric SarcomasSemantic proximity Read

Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapiesSemantic proximity Read

Mapping Genomic Heterogeneity in Pediatric and Adolescent-Young Adult Sarcomas: Insights from the Italian SAR-GEN2016 and SAR-GEN_ITA Prospective Multicenter Trials.Semantic proximity Read

<i>PAX</i> fusion proteins deregulate gene networks controlling mitochondrial translation in pediatric rhabdomyosarcomaSemantic proximity Read

Biological and clinical implications of FGFR aberrations in paediatric and young adult cancers.Semantic proximity Read

Personalized Zebrafish Models for Fusion‐Positive Pediatric SarcomasSemantic proximity Read

Current management of neurotrophic receptor tyrosine kinase fusion-positive sarcoma: an updated reviewSemantic proximity Read

Pediatric Patient-Derived-Xenograft development in MAPPYACTS – international pediatric cancer precision medicine trial in relapsed and refractory tumorsSemantic proximity Read