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Article

Multi-omic and immune landscapes of HPV-negative versus HPV-positive cervical cancer reveal implications for immunotherapy.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Apr 2026

Zhang Guo, Zhang Xiaobo, Li He, Du Xinqiao, Wang Jianliu

Abstract excerpt

BACKGROUND: HPV-negative cervical cancer (3-8% of cases) presents distinct clinical challenges and poorer prognosis compared to HPV-positive disease. We aimed to conduct an exploratory study to characterize its unique tumor immune microenvironment (TIME) and molecular drivers to inform immunotherapy development. METHODS: We analyzed 70 cervical cancer patients (50 HPV-positive/HPV-A, 20 HPV-negative/HPV-I) using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41795431
DOI: 10.1016/j.ejso.2026.111425

Genes

PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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