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Microbiome Profiling Reveals Gut Dysbiosis in the Metabotropic Glutamate Receptor 5 Knockout Mouse Model of Schizophrenia

29 Oct 2020

Abstract excerpt

Schizophrenia (SZ) is a psychiatric disorder that constitutes one of the top 10 global causes of disability. More recently a potential pathogenic role for the gut microbial community (microbiota) has been highlighted. However, no animal model of SZ has previously recapitulated the gut dysbiosis observed clinically. The metabotropic glutamate receptor 5 (mGlu5) knockout mice provide a preclinical model of SZ with...

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PMID: 33195226
DOI: 10.3389/fcell.2020.582320

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