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Article

Learning the language of protein-protein interactions.

Nature communications - 7 Jan 2026

Ullanat Varun, Jing Bowen, Sledzieski Samuel, Berger Bonnie

Abstract excerpt

Protein Language Models (PLMs) trained on large databases of protein sequences have proven effective in modeling protein biology across a wide range of applications. However, while PLMs excel at capturing individual protein properties, they face challenges in natively representing protein-protein interactions (PPIs), which are crucial to understanding cellular processes and disease mechanisms. Here, we introduce...

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Identifiers

PMID: 41501061
DOI: 10.1038/s41467-025-67971-3
PMCID: PMC12859026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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