Article
Strategy for identification of a potential inherited leukemia predisposition in a 299 patient's cohort with tumor-only sequencing data.
Leukemia research - 1 Aug 2020
Aguilera-Diaz Almudena, Larrayoz María José, Palomino-Echeverría Sara, Vazquez Iria, Ariceta Beñat, Mañú Amagoia, Blasco-Iturri Zuriñe, Bernal Del Castillo Teresa, Olivares Salaverri Matxalen, Olave Rubio Maria Teresa, Rifon-Roca Jose, Alfonso-Pierola Ana, Prosper Felipe, Fernandez-Mercado Marta, Calasanz María José
Abstract excerpt
Myeloid neoplasms (MN) are usually sporadic late-onset cancers; nevertheless, growing evidence suggests that ∼5% of the cases could emerge as a consequence of inherited predisposition. Distinguishing somatic from germline variants is of vital importance, in order to establish an appropriate individualized management and counsel the patients and their relatives. Since many of the genes associated with myeloid...
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