[Clinical significance of germline pathogenic variants associated with hematologic malignancies].

Abstract excerpt

The onset of hematologic malignancies is influenced not only by acquired somatic mutations but also by pathogenic germline variants to a broader extent than previously assumed. Although germline predisposition was traditionally thought to be limited to inherited bone marrow failure syndromes such as Fanconi anemia or to characteristic familial cases, pathogenic variants in RUNX1, ETV6, GATA2, and DDX41 are now...

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