Article
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1993
Lubahn D B, Moyer J S, Golding T S, Couse J F, Korach K S, Smithies O
Abstract excerpt
Estrogen receptor and its ligand, estradiol, have long been thought to be essential for survival, fertility, and female sexual differentiation and development. Consistent with this proposed crucial role, no human estrogen receptor gene mutations are known, unlike the androgen receptor, where many loss of function mutations have been found. We have generated mutant mice lacking responsiveness to estradiol by...
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