Article
Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy.
Current biology : CB - 10 Aug 2004
Miller Brooke H, Olson Susan Losee, Turek Fred W, Levine Jon E, Horton Teresa H, Takahashi Joseph S
Abstract excerpt
Classic experiments have shown that ovulation and estrous cyclicity are under circadian control and that surgical ablation of the suprachiasmatic nuclei (SCN) results in estrous acyclicity in rats. Here, we characterized reproductive function in the circadian Clock mutant mouse and found that the circadian Clock mutation both disrupts estrous cyclicity and interferes with the maintenance of pregnancy. Clock...
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