Article
Endocrine defects in mice carrying a null mutation for the progesterone receptor gene.
Endocrinology - 1 Oct 1997
Chappell P E, Lydon J P, Conneely O M, O'Malley B W, Levine J E
Abstract excerpt
Mice carrying a null mutation of the progesterone receptor gene exhibit several reproductive abnormalities, including anovulation, attenuated lordotic behavior, uterine hyperplasia, and lack of mammary gland development. The hormonal correlates of these abnormalities are unknown, however, and wer...
Topics
- Animals
- Anovulation
- Brain Chemistry
- Estrogens
- Female
- Follicle Stimulating Hormone
- Gonadotropin-Releasing Hormone
- Hyperplasia
- Hypothalamus
- Luteinizing Hormone
- Male
- Mammary Glands, Animal
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Ovariectomy
- Pituitary Gland