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Article

DNA‐Binding Small Molecules as Inhibitors of Transcription Factors

30 Apr 2012

Abstract excerpt

Accumulating evidence implicating the role of aberrant transcription factor signaling in the pathogenesis of various human diseases such as cancer and inflammation has stimulated the development of small molecule ligands capable of targeting transcription factor activity and modulating gene expression. The use of DNA-binding small molecules to selectively inhibit transcription factor-DNA interactions represents...

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PMID: 22549740
DOI: 10.1002/med.21266

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