Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS models

27 Oct 2021

Abstract excerpt

is a strategy for mitigating c9ALS/FTD-associated pathologies and studying disease-associated pathways in preclinical models.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Genetics and Neurodevelopmental Disorders
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34705518
DOI: 10.1126/scitranslmed.abd5991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS modelsPMID 34705518Read ↗

Therapeutic strategies for C9orf72 amyotrophic lateral sclerosis and frontotemporal dementiaSemantic proximity Read ↗

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense InterventionSemantic proximity Read ↗

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAsSemantic proximity Read ↗

Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In VivoSemantic proximity Read ↗

Unraveling the Role of RNA Mediated Toxicity of C9orf72 Repeats in C9-FTD/ALSSemantic proximity Read ↗

Development of Therapeutics for C9ORF72 ALS/FTD-Related DisordersSemantic proximity Read ↗

Arginine-rich dipeptide-repeat proteins as phase disruptors in C9-ALS/FTDSemantic proximity Read ↗

An amyloid-like cascade hypothesis for C9orf72 ALS/FTDSemantic proximity Read ↗

RNA-mediated toxicity in C9orf72 ALS and FTDSemantic proximity Read ↗

A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTDSemantic proximity Read ↗

Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes.Semantic proximity Read ↗

Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.