Article

A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes

2022-02-28

Abstract excerpt

Translation of the hexanucleotide G4C2 expansion associated with C9orf72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (ALS/FTD) produces five different dipeptide repeat protein (DPR) species that can confer toxicity. There is yet much to learn about the contribution of a single DPR to disease pathogenesis. We show here that a short repeat length is sufficient for the DPR poly-GR to confer neurotoxicit...

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Literature Corpus work: 087e4d94-66d6-59dd-9718-c547c704281f
DOI: 10.21203/rs.3.rs-1096745/v2

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