Article

Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clusters

2024-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Circulating tumor cell (CTC) clusters are often detected in blood samples of patients with high-grade tumor and are associated with tumor metastasis and poor prognosis. However, the underlying mechanisms by which CTC clusters are released from primary tumors beyond blood vessel barriers remain unclear. In this study, a three-dimensional (3D) in vitro culture system is developed to visualize tumo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3fa70ce0-7101-5d89-b9b1-3d9674fe128c
DOI: 10.1101/2024.02.28.582606

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clustersDOI 10.1101/2024.02.28.582606Read

A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasationSemantic proximity Read

Tumor microenvironment complexity and therapeutic implications at a glanceSemantic proximity Read

Circulating tumor cell clusters: What we know and what we expect (Review)Semantic proximity Read

Cell‐Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer CellsSemantic proximity Read

Emerging approaches to study cell-cell interactions in tumor microenvironmentSemantic proximity Read

Multicompartmentalized microvascularized tumor-on-a-chip to study tumor-stroma interactions and drug resistance in ovarian cancerSemantic proximity Read

How circulating tumor cluster biology contributes to the metastatic cascade: from invasion to dissemination and dormancySemantic proximity Read

Microfluidic vascular models of tumor cell extravasationSemantic proximity Read

Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potentialSemantic proximity Read

Modeling the role of urokinase plasminogen activator, uPA, and circulating Cancer-Associated Fibroblasts (cCAFS) in breast cancer cell extravasationSemantic proximity Read

Circulating tumor cell clusters: Insights into tumour dissemination and metastasisSemantic proximity Read

En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal TransitionSemantic proximity Read