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How circulating tumor cluster biology contributes to the metastatic cascade: from invasion to dissemination and dormancy

13 Jul 2023

Abstract excerpt

Circulating tumor cells (CTCs) are known to be prognostic for metastatic relapse and are detected in patients as solitary cells or cell clusters. Circulating tumor cell clusters (CTC clusters) have been observed clinically for decades and are of significantly higher metastatic potential compared to solitary CTCs. Recent studies suggest distinct differences in CTC cluster biology regarding invasion and survival in...

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PMID: 37442876
DOI: 10.1007/s10555-023-10124-z

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