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A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation

24 Apr 2025

Abstract excerpt

Circulating tumor cell (CTC) clusters are often detected in blood samples of patients with high-grade tumor and are associated with tumor metastasis and poor prognosis. However, the underlying mechanisms by which cancer cell clusters are released from primary tumors beyond blood vessel barriers remain unclear. In this study, a three-dimensional (3D) in vitro culture system was developed to visualize tumor...

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PMID: 40491477
DOI: 10.1016/j.isci.2025.112517

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