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The secret life of complement: challenges and opportunities in exploring functions of the complosome in disease

15 Jun 2025

Abstract excerpt

The complement system is a highly conserved and essential immune component with pivotal roles in innate and adaptive immunity. It is increasingly recognized that the complement system has a profound impact on disease. Current complement-targeting therapeutics for clinical use almost exclusively target the complement system in circulation. However, recent discoveries have demonstrated that complement is not only...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40519170
DOI: 10.1172/jci188350

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