Article

Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals

2025-01-06

Abstract excerpt

In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA 1 . As of mid-2025 the epidemic is ongoing, resulting in spillbacks into poultry, wild birds and other mammals including humans 2 . Here, we present molecular and virological evidence that the cattle B3.13 genotype H5N1 viruses rapidly accumulated adaptations in polymerase genes that enable...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ec04451-0f75-5062-919e-8a256ad518aa
DOI: 10.1101/2025.01.06.631435

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammalsDOI 10.1101/2025.01.06.631435Read

Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.Semantic proximity Read

Emergence of mammalian-adaptive PB2 mutations enhances polymerase activity and pathogenicity of cattle-derived H5N1 influenza A virus.Semantic proximity Read

Genomic characterization of highly pathogenic avian influenza A H5N1 virus newly emerged in dairy cattle.Semantic proximity Read

Highly Pathogenic Avian Influenza A (H5N1) clade 2.3.4.4b Virus detected in dairy cattleSemantic proximity Read

Identification of amino acid residues in polymerase PB2 responsible for differential replication and pathogenicity of avian influenza virus H5N1 isolated from human and cattle in Texas, USSemantic proximity Read

Bovine H5N1 influenza viruses have adapted to more efficiently use receptors abundant in cattleSemantic proximity Read

Identification of Amino Acid Residues Responsible for Differential Replication and Pathogenicity of Avian Influenza Virus H5N1 Isolated from Human and Cattle in Texas, USSemantic proximity Read

H5N1 2.3.4.4b: a review of mammalian adaptations and risk of pandemic emergence.Semantic proximity Read

Primary bovine embryonic fibroblasts support seasonal influenza A virus infection and demonstrate variable fitness of HPAI H5N1Semantic proximity Read

Genotype B3.13 influenza A(H5N1) viruses isolated from dairy cattle demonstrate high virulence in laboratory models, but retain avian virus-like propertiesSemantic proximity Read

Cellular tropism of highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b viruses in human respiratory and bovine mammary epithelial cells.Semantic proximity Read

The potential of H5N1 viruses to adapt to bovine cells varies throughout evolutionSemantic proximity Read