Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emergence of mammalian-adaptive PB2 mutations enhances polymerase activity and pathogenicity of cattle-derived H5N1 influenza A virus.

Nature communications - 20 Dec 2025

Zhang Lei, Lai Yuerong, Cui Yingzi, Yang Qiuxian, Shao Yuekun, Ding Shenyang, Wang Haojie, Wang Liang, Gao George Fu, Deng Tao

Abstract excerpt

Highly pathogenic avian influenza H5N1 poses an increasing public health risk, particularly following its spillover into dairy cows and associated human infections in the U.S. since March 2024. Here, we systematically identified critical PB2 mutations emerged during avian-to-cattle transmission and subsequent adaptation in cattle, notably PB2 M631L, which conferred pathogenicity in mice comparable to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cattle Diseases
Share to Influenza A Virus, H5N1 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza, Human

Share to Influenza in Birds

Share to Orthomyxoviridae Infections

Share to RNA-Dependent RNA Polymerase

Share to Viral Proteins

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 41422038
DOI: 10.1038/s41467-025-67753-x
PMCID: PMC12847931

Genes

ANP32A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emergence of mammalian-adaptive PB2 mutations enhances polymerase activity and pathogenicity of cattle-derived H5N1 influenza A virus.PMID 41422038Read ↗

Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammalsSemantic proximity Read ↗

Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.Semantic proximity Read ↗

Identification of amino acid residues in polymerase PB2 responsible for differential replication and pathogenicity of avian influenza virus H5N1 isolated from human and cattle in Texas, USSemantic proximity Read ↗

Genomic characterization of highly pathogenic avian influenza A H5N1 virus newly emerged in dairy cattle.Semantic proximity Read ↗

Identification of Amino Acid Residues Responsible for Differential Replication and Pathogenicity of Avian Influenza Virus H5N1 Isolated from Human and Cattle in Texas, USSemantic proximity Read ↗

Highly Pathogenic Avian Influenza A (H5N1) clade 2.3.4.4b Virus detected in dairy cattleSemantic proximity Read ↗

Dynamics of a Panzootic: Genomic Insights, Host Range, and Epidemiology of the Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b in the United StatesSemantic proximity Read ↗

Expanding Horizons: Host Range Evolution and Treatment Strategies for Highly Pathogenic H5N1 Avian InfluenzaSemantic proximity Read ↗

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hostsSemantic proximity Read ↗

An emerging PB2-627 polymorphism increases the zoonotic risk of avian influenza virus by overcoming ANP32 host restriction in mammalian and avian hostsSemantic proximity Read ↗

H5N1 2.3.4.4b: a review of mammalian adaptations and risk of pandemic emergence.Semantic proximity Read ↗

A single PA-X mutation in bovine-origin H5N1 influenza virus reduces pathogenicity in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.