Article

Improved targeting and elicitation of VRC01-class precursors by an optimized glycan-masking mutant of OD-GT8

2025-08-04

Abstract excerpt

<title>Abstract</title> <p>VRC01-class broadly neutralizing antibodies (bnAbs) target the conserved CD4-binding site (CD4bs) on the HIV-1 envelope. An engineered envelope outer domain eOD-GT8 60mer nanoparticle elicits VRC01-class precursors but also significant off-target responses in transgenic mice and humans, limiting on-target bnAb development. To mask off-target epitopes, N-linked glycans were engineered in...

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Literature Corpus work: 3e864952-db43-5882-87f2-6dc5b7910059
DOI: 10.21203/rs.3.rs-6941578/v1

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