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The Spatial Organization of DNA Virus Genomes in the Nucleus

27 Jun 2013

Abstract excerpt

During lytic infection, DNA viruses that replicate in the nucleusof cells establish an environment that favors viral replication whileevading cellular defenses. Consequently, these viruses must engagewith cellular factors that are necessary for efficient viraltranscription and DNA replication, while disarming restrictivecellular responses to the presence of the invading pathogenicDNA. It is important to consider...

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PMID: 23825941
DOI: 10.1371/journal.ppat.1003386

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