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NKG2D Ligand MICA Is Retained in the<i>cis</i>-Golgi Apparatus by Human Cytomegalovirus Protein UL142

1 Oct 2009

Abstract excerpt

Human cytomegalovirus (HCMV) evades T-cell recognition by down-regulating expression of major histocompatibility complex (MHC) class I and II molecules on the surfaces of infected cells. Contrary to the "missing-self" hypothesis, HCMV-infected cells are refractory to lysis by natural killer (NK) cells. Inhibition of NK cell function is mediated by a number of HCMV immune evasion molecules, which operate by...

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PMID: 19793804
DOI: 10.1128/jvi.01175-09

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