Article

Targeting transforming growth factor-β2 by antisense oligodeoxynucleotide accelerates T cell-mediated tumor rejection in a humanized mouse model of triple-negative breast cancer

2021-04-05

Abstract excerpt

<h4>Background: </h4> : Transforming growth factor (TGF-β) pathway mediates suppression of anti-tumor immunity, and is associated with poor prognosis in triple-negative breast cancer (TNBC). <h4>Methods: </h4> : In this study, we generated a humanized animal model by transplanting human peripheral blood mononuclear cells into immunodeficient mice followed by inoculation of MDA-MB-231 cells, and subsequently analyz...

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Literature Corpus work: 3e58a87c-dcf8-565b-95a1-bdbabbbc2c41
DOI: 10.21203/rs.3.rs-363729/v1

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