Article

Crb2-dependent progenitor adhesion safeguards ventricular lining integrity and prevents hydrocephalus

2026-08-13

Abstract excerpt

<title>Abstract</title> <p>Congenital hydrocephalus is a heterogeneous neurodevelopmental disorder in which ventricular enlargement can arise from impaired cerebrospinal fluid (CSF) flow, aqueductal obstruction, or altered ventricular wall integrity. Although human CRB2 mutations are associated with hydrocephalus, aqueductal abnormalities, and periventricular heterotopia, the relevant cell types and pathogenic se...

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Literature Corpus work: 3e3d671a-5edc-56b2-9faa-640fa8ba7a1a
DOI: 10.21203/rs.3.rs-10244145/v1

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