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Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

10 Sept 2018

Abstract excerpt

Transfer RNAs (tRNAs) are non-coding RNA molecules essential for protein synthesis. Post-transcriptionally they are heavily modified to improve their function, folding and stability. Intronic polymorphisms in CDKAL1, a tRNA methylthiotransferase, are associated with increased type 2 diabetes risk. Loss-of-function mutations in TRMT10A, a tRNA methyltransferase, are a monogenic cause of early onset diabetes and...

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PMID: 30247717
DOI: 10.1093/nar/gky839

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