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Prophylactic donor-derived CD19 CAR-T cell infusion for preventing relapse in high-risk B-ALL after allogeneic hematopoietic stem cell transplantation

17 Apr 2024

Abstract excerpt

Relapse remains a key cause of transplant failure in high-risk B-cell acute lymphoblastic leukemia (B-ALL). Nevertheless, the available maintenance therapy for relapse prevention after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in high-risk B-ALL, especially in Ph-negative B-ALL patients, has limitations and suboptimal efficacy. Notably, donor-derived anti-CD19 chimeric antigen receptor T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38632315
DOI: 10.1038/s41375-024-02251-5

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