Multicellular Spatial Programs Define the Histopathological Architecture of Meningioma

Abstract excerpt

<h4>SUMMARY</h4> Tumors are often described by cell types or gradients, but the organizing units of tumor tissue remain unclear. Using meningiomas, which show marked morphologic diversity despite constrained and recurrent genetics, we identify reproducible multicellular spatial molecular programs (SMPs) characterized by recurring cell-type mixtures that combine in different proportions across tumors. We built a m...

Topics

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• Data Analysis
• DNA Methylation
• Drug Discovery
• Glioma Diagnosis and Treatment
• Meningioma
• Meningioma and schwannoma management
• Proteogenomics
• Reproducibility of Results

Identifiers and source

Literature Corpus work

3e23f07b-92a6-56e8-848a-cdd13a93c559

DOI

10.64898/2026.06.16.732172