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Article

Probing the kinetic stabilities of Friedreich's ataxia clinical variants using a solid phase GroEL chaperonin capture platform.

Biomolecules - 20 Oct 2014

Correia Ana R, Naik Subhashchandra, Fisher Mark T, Gomes Cláudio M

Abstract excerpt

Numerous human diseases are caused by protein folding defects where the protein may become more susceptible to degradation or aggregation. Aberrant protein folding can affect the kinetic stability of the proteins even if these proteins appear to be soluble in vivo. Experimental discrimination between functional properly folded and misfolded nonfunctional conformers is not always straightforward at near...

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Identifiers

PMID: 25333765
DOI: 10.3390/biom4040956
PMCID: PMC4279165

Genes

FXN

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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