Article

Aquaporin-4–Specific T Cell Responses in NMOSD Revealed by mRNA-Engineered Dendritic Cells

2026-06-09

Abstract excerpt

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system characterized by loss of immune tolerance to the water channel aquaporin-4 (AQP4). Current therapies do not specifically restore AQP4 tolerance or selectively suppress antigen-specific immune responses. Reprogramming patient’s own dendritic cells (DCs) with mRNA to induce tolerance represents a promising therapeut...

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Literature Corpus work: 3e141c4e-3ee6-5c43-9f89-6f1b3eb21dc2
DOI: 10.64898/2026.06.05.730365

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