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Article

Characterization of the binding pattern of human aquaporin-4 autoantibodies in patients with neuromyelitis optica spectrum disorders.

Journal of neuroinflammation - 1 Jul 2016

Tuller Friederike, Holzer Hannah, Schanda Kathrin, Aboulenein-Djamshidian Fahmy, Höftberger Romana, Khalil Michael, Seifert-Held Thomas, Leutmezer Fritz, Berger Thomas, Reindl Markus

Abstract excerpt

BACKGROUND: The discovery of a highly specific antibody against the aquaporin-4 (AQP4) water channel (AQP4-IgG) unified the spectrum of neuromyelitis optica spectrum disorders (NMOSD), which are considered to be antibody-mediated autoimmune diseases. The AQP4 water channel is located on astrocytic end-feet processes and consists of six transmembrane helical domains forming three extracellular loops A, C, and E in...

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Source

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Identifiers

PMID: 27371173
DOI: 10.1186/s12974-016-0642-3
PMCID: PMC4930584

Genes

AQP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of the binding pattern of human aquaporin-4 autoantibodies in patients with neuromyelitis optica spectrum disorders.PMID 27371173Read ↗

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