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[Dynamically monitoring circulating tumor DNA as a biomarker for immunotherapy in advanced esophageal squamous cell carcinoma].

Zhonghua zhong liu za zhi [Chinese journal of oncology] - 23 Aug 2026

Wang B Y, Wang H K, Li J, Ye S S, Xu J M

Abstract excerpt

Objective: To investigate the clinical value of dynamic monitoring of plasma circulating tumor DNA (ctDNA) in evaluating the efficacy of immunotherapy for esophageal squamous cell carcinoma (ESCC). Methods: Plasma samples were collected at baseline and after every 2-3 treatment cycles from 94 patients with advanced ESCC receiving second-line sintilimab monotherapy in the ORIENT-2 study. Targeted sequencing was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42595554
DOI: 10.3760/cma.j.cn112152-20251210-00608

Genes

NOTCH1
CDKN2B
TP53
CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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