Article

Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases

2025-12-12

Abstract excerpt

<title>Abstract</title> <p>The innate immune response is a first line of defense that allows a rapid reaction to pathogens as well as molecules released from damaged cells. It relies on pathogen sensing receptors many of which are nucleic acid-binding proteins including RNA helicases. Plakophilin 1 (PKP1) is a desmosomal protein essential for strong intercellular adhesion and epithelial barrier integrity. Loss-of...

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Literature Corpus work: 3d83970f-3fbd-5669-ac90-c8577756902b
DOI: 10.21203/rs.3.rs-7582528/v1

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