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Article

Effects of cell phenotype and seeding density on the chondrogenic capacity of human osteoarthritic chondrocytes in type I collagen scaffolds.

Journal of orthopaedic surgery and research - 30 Mar 2020

Cao Chenxi, Zhang Yujun, Ye Yanqi, Sun Tiezheng

Abstract excerpt

OBJECTIVE: Matrix-associated autologous chondrocyte implantation (MACI) achieves good clinical efficacy in young patients with focal cartilage injury; however, phenotypic de-differentiation of chondrocytes cultured in monolayer and the treatment of older OA patients are still challenges in the field of cartilage tissue engineering. This study aimed to assess the in vitro re-differentiation potential and in vivo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32228637
DOI: 10.1186/s13018-020-01617-6
PMCID: PMC7104498

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